A new drug is undergoing testing, at 10am 100mg is given to a patient. At 10pm a blood sample is taken from the patient and the patient is found to have 12.5mg of the drug circulating.

Which of the following best describes the half-life of this drug?

A) 2 hours
B) 4 hours
C) 6 hours
D) 8 hours
E) 10 hours

A gentleman aged 55 years old is found to have hypertension, which of the following is the best drug treatment for him to start on?

A) Nifedipine
B) Ramipril
C) Losartan
D) Doxazosin
E) Bendroflumethiazide

Match the drug to it's target and the expected physiological effect:

A) Propranolol - beta adrenoreceptor - slowed sino-atrial node conduction
B) Domperidone - histamine receptor - antiemetic
C) Aspirin - thromboxane A2 - increased platelet aggregation
D) Salbutamol - alpha adrenoreceptor - dilates bronchial smooth muscle
E) Methotrexate - DNA transcriptase - decreased nucleic acid synthesis

Which of the following is true about Warfarin?

A) Warfarin inhibits Vitamin E dependant clotting factors 6 and 8.
B) Warfarin promotes production of endogenous anticoagulants such as protein S.
C) Warfarin inhibits carboxylation of clotting factors 9 and 10.
D) Warfarin inhibits only the extrinsic pathway and so Heparin is commonly prescribed as well.
E) Warfarin is used in the acute setting for thrombolysis.