With regards to anaemia, which of the following is correct?

A) Folate deficiency causes a macrocytic anaemia.

B) Sickle cell disease commonly presents with fatigue due to haemolysis of red blood cells.

C) Normocytic anaemia does not have a malignant cause.

D) Iron deficiency is a rare cause of microcytic anaemia.

E) Acute blood loss results in a microcytic anaemia.

The answer is A. 

Folate deficiency can be due to decreased intake or malabsorption, e.g. coeliac disease. Sickle cell disease does cause haemolysis of red blood cells but the common presentation is due to bone pain, not fatigue. Normocytic anaemia can be caused by myeloma and leukaemia. Iron deficiency is the most common cause of microcytic anaemia. Acute blood loss results in a normocytic anaemia.